The Human SARS-CoV-2 Serology Standard is a pool of plasma from four donors with antibodies IgM and IgG to the SARS-CoV-2 spike and nucleocapsid proteins. The U.S. standard has been calibrated to the WHO International Standard.
The goal of a serology standard is to harmonize assays that measure anti-SARS-CoV-2 antibodies and to enable comparisons between different studies, including different candidate COVID-19 vaccines. This serology standard is to be used for calibration purposes by laboratories conducting SARS-CoV-2 serology testing, rather than for routine inclusion as a quality control.
Email SSNCCbiospecimens@nih.gov with the request form and/or questions.
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Development and assays
This standard has been assigned ligand binding assay units and neutralizing units based on a collaborative study from eight different laboratories and several types of assays:
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Automated chemiluminescence
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Manufacturer developed ligand binding
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In-house developed ligand binding
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Fluorescence reduction neutralization